Sildenafil, Tadalafil and Vardenafil

I took Viagra and had a 2 day jack fest (I’m 32). My cock and balls swelled and got huge, then a couple days later went back to normal (I’m pretty well hung, honest 8" when back to normal). Was it the Viagra or did I over do it? I shot a load about 11 times over those days, thick strings to start then thinner clearer spunk at the end of the session. I figure I’d ask a pro! What do you think?
Let me explain how Sildenafil, Tadalafil and Vardenafil work and you’ll see that what you said you experienced cannot be caused by any of these medications.

Sildenafil, Tadalafil and Vardenafil are phosphodiesterase-5 inhibitors (PDE5-i). To understand how they work, we must first understand how an erection happens.

Erection is a complex phenomenon involving psychological, neurological and vascular integrity and interactions.

1. The erection process begins in the brain first and foremost. This process is triggered by mental imagery or by physical stimulation (visual, auditory or tactile perceptions, including sensual caresses aimed squarely at the penis itself). If the perception of the stimulation is favourable, the brain sends an appropriate response to the brainstem. The psychological step is basically an on/off switch. 90 % of the erectile dysfunction problems happen at this step and PDE5-i won’t work here. Most men taking PDE5-i want to have an erection, however, so their mental switch is usually on…
2. The neurological response then begins : from this step on, the erection becomes a series of reflex actions evolving in an explosive fashion up to the visually impressive finale. The nerves, amongst other things, stimulate certain cells in the vasculature of the penis, triggering in turn the vascular step. (Still no PDE5-i here.)
3. The cells stimulated by the aforementioned nerves release nitric oxide (NO) in the vasculature of the corpus cavernosum.
4. NO activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP).
5. This leads to smooth muscle relaxation in blood vessels supplying the corpus cavernosum
6. Consequently, there is an increased blood flow to the penis while blood flow out of the penis stays the same (it may decrease).
7. At this point, since there is thus more blood going in the penis than blood going out, the dramatic effect called an erection happens !

As you can see, erection is a series of positive reactions to a stimulation from the moment the neurological system is triggered. Contrary to the psychological phase where there is a choice (yes/no), the rest of the erectile sequence is a straightforward yes, a domino effect. So as long as there is a minimal favourable psychological response, neurological stimulation continues and, consequently, liberation of NO by the perivascular cells in the corpus cavernous.
Ok, now… Having an erection is fine and all, but how does one loses his erection ? All good things has an end !

1. You remember that the increased blood flow to the penis happens because of the smooth muscle relaxation in blood vessels supplying the corpus cavernosum.
2. You might also remember that this relaxation happens as a response to the increased levels of cyclic guanosine monophosphate (cGMP).
3. From the moment cGMP is released, an enzyme kicks in to degrade (destroy) this cGMP : this enzyme is the Phosphodiesterase-5 (PDE5). A-Ha : there we are !
4. For as long as there is arousal, cGMP is released more quickly than PDE5 can deactivate it, leading to a sustained erection.
5. But when the arousal ceases, PDE5 eventually succeeds in deactivating all the cGMP.
6. When this happens, the relaxation of the smooth muscles in blood vessels supplying the corpus cavernosum ceases and the outflow is again greater than the inflow : this is detumescence (loss of erection).

So we finally found the spot where the phosphodiesterase-5 inhibitors (PDE5-i) has an effect ! Quite logically indeed, phosphodiesterase-5 inhibitors (PDE5-i) inhibit the degradation of cGMP by phosphodiesterase type 5 (PDE5). Since there is less PDE5 to do the job, there is more cGMP available to act on the walls of the blood vessels supplying the corpus cavernous, increasing blood flow to the penis during sexual stimulation, hence increasing the likelihood of a successful erection.
All in all, what does this mean ? It means that Sildenafil, Tadalafil and Vardenafil only work on a single step (albeit an important one) of the whole erection process. The rest is not impacted in anyway. It also means that PDE5 inhibitors are totally ineffective without sexual stimulation. It won’t give you an erection without your consent, so to speak.

What is the point, then, of this medication ?

1. For men with a bad vascular health (cholesterol deposits partially clogging the arteries for instance), the relaxation of the smooth muscles in blood vessels supplying the corpus cavernous may not result in sufficient blood flow to result in an input/output ratio adequate enough to allow the penis to become hard enough (soft erection problem) or stay hard long enough (stamina problem). PDE5-i, by increasing the longevity of the cGMP, helps then.
2. For men who’d like to but are too tired to perform, PDE5-i will help pick up the slack. This is why porn actors use PDE5-i abundantly : after ejaculation, the penis goes into a recess phase and PDE5-i shorten this recess phase drastically. This last reason is also the only one that explains how these pills could be interesting for healthy younger men. In other words, healthy younger men using PDE5-i won’t see any change in the quality (firmness and stamina) of their erection. If you are young and need PDE5-i, have yourself checked for cholesterol and diabetes !

How long do the PDE5-i act ?

• Sildenafil and Vardenafil stay in the blood in sufficient concentration to be active for 6 hours
• Tadalafil stays in the blood in sufficient concentration to be active for 36 hours, hence its nickname of the week-end pill.

Back to your question :

Can a 2 days fest resulting in swollen balls and cock be caused by Sildenafil (Viagra) ? The answer is totally and completely negative. As we have seen, Viagra only acts 6 hours (so 2 days are way out of the question) and it only dilates small blood vessels (so the swollen genitals are out). Additionally, since Viagra does not act on the prostate, it cannot increase the volume of semen.
I’m sorry if I burst your bubble though.

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